In 2014, the cost of human whole genome sequencing was reduced to US$1,000. The global genetic testing field ushered in the first spring, and China's genetic testing market was exploding. In 2017, Illumina once again reduced the cost of whole genome sequencing to $800. While sequencing costs are decreasing, genomic data worldwide is also increasing at super-molar rates. The calculation and interpretation of genetic data has always been an important part of genetic testing. In the case of a surge in data, how to analyze and interpret data faster and more accurately will be the next proposition in the field of genetic testing.
The first gene is a company that combines biological and IT technologies focused on gene big data. The company has an interdisciplinary R&D team that has been engaged in gene sequencing , molecular biology, algorithm development, and big data processing for many years. It is committed to building a world-class bioinformatics analysis center and establishing a nationally authoritative genetic information database.
Tang Yuanhua, founder and CEO of the first gene
Founder Tang Yuanhua told reporters: "The Chinese population accounts for 1/4 of the world's total population, but the genetic data research for Chinese is far lower than that of Europeans and Americans. Therefore, we want to focus on building Chinese genetic databases, including ethnic groups. The mutation of genes and cancer."
Cross-border: scientists who find the most human genes in the world
Prior to founding the first gene, Tang Yuanhua served as the head of the bioinformatics department at several biotech companies in the United States. From a personal resume, this is an expert in bioinformatics. However, Tang Yuanhua told reporters that he was born from a mathematical background, which made the reporter quite surprised.
Tang Yuanhua recalled: "When I went to the United States, it was 1988. At that time, the Human Genome Project was in preparation. On the first day of my school, James Watson gave a speech at our school. The speech completely changed my life track."
Tang Yuanhua described himself as an idealist. He went to the United States to learn the most advanced science and technology in the West. "When I heard the Human Genome Project, comparable to the Apollo Moon Landing Program and the Manhattan Atomic Bomb Project, isn't that the purpose of my coming to the United States?" Tang Yuanhua, who was originally a math student, decided to turn to genomics research.
The formal presentation of the concept of bioinformatics was in 1993. During Tang Yuanhua’s reading, there was no professional biology information in the world, but this general trend was there. The mathematics student, the problem of doctoral thesis research, is the direction of life science. After graduation, Tang Yuanhua devoted himself to the Human Genome Project, and the team led to discover more than 20% of human genes. He is the world's most discovered scientist, and has discovered and named four important gene families.
"Bioinformatics was still a virgin discipline at that time, and it did not have its own theoretical system. For many people, life science is an experimental science. Learning it mainly depends on memory." Tang Yuanhua recalled. He told reporters that there were some mathematicians who hoped to establish the theoretical foundation of life sciences: "This is the background of the time. A group of scientists in the mathematics community hope to find a unified theory that can explain all life phenomena."
After nearly 30 years of development, "theoretical biology" has developed to a very successful level. The foundation of life science has been implemented on the basis of informatics. It is even said that it has become a homologous discipline with computer science. Today, biologists' understanding of the nature of life has transcended physicists' understanding of the physical world. (Because the essence of life is implemented at the level of DNA, the experiment can be fully contacted. Theoretical physics is still limited by experimental methods). Being able to do some groundbreaking work in the field of life informatics, Tang Yuanhua said that he feels very proud.
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