Release date: 2014-11-04
According to the Science Daily, a team led by scientists at the Lawrence Livermore National Laboratory recently created an ion channel containing short carbon nanotubes that can be inserted into a synthetic phospholipid bilayer or a living cell membrane to form Small holes for transporting water, protons, small ions and DNA.
These carbon nanotube "membrane porins" have important implications for future health care and bioengineering. Carbon nanotubes will eventually be used to deliver drugs to the body, as a basis for novel biosensors and DNA sequencing applications, and can be used to synthesize cellular components.
Researchers have long been interested in the development of synthetic analogs of biological cell membrane channels that can replicate the high efficiency and extreme selectivity of transporting particles and molecules, the latter common in natural systems. However, these efforts always face some problems in synthetics, and scientists seem to never fully mimic the performance of biological proteins.
Tablets that are generally taken are slowly absorbed by the body and transported throughout the body, but carbon nanotubes differ in that they determine a precise area to be treated without harming other organs around them. “Many high-efficiency drugs that treat an organ disease can be toxic to other organs,†says Aleksandr Noy, a biophysicist at Lawrence Livermore National Laboratory, who led the research. “That’s why it’s better to transfer the drug to a specific area of ​​the body and only release it there.†The study was published in the October 30 issue of Nature.
Lawrence Livermore National Laboratory's research team and colleagues at the Lawrence Berkeley National Laboratory's Department of Molecular Materials, the University of California at Merced and Berkeley, and the Spanish National University of Basque used carbon nanotubes to create a more efficient, biological A compatible membrane pore channel, carbon nanotubes are a straw-like molecule that contains a rolled up graphene film.
This study shows that although the structure of carbon nanotubes is relatively simple, carbon nanotube membrane porins have many characteristic behaviors of natural ion channels: they can spontaneously insert into cell membranes, can switch between metastable conductance states, and exhibit typical The barrier properties induced by polymers. The team also found that, similar to the situation in biological channels, local channels and cell membrane charge can also control the ionic conductivity and ion selectivity of carbon nanotube membrane porin.
"We found these nanopores to be very promising biomimetic platforms for developing cell interfaces, studying transmissions in biological pathways, and creating biosensors," said Noy. “We are thinking about carbon nanotube porins or perhaps the first versatile man-made nanopore that can be used in a wide range of applications in biology and materials science.â€
“All in all, our findings confirm that carbon nanotubes are well promising prototypes of synthetic membrane channels that are inherently robust against biological and chemical challenges while providing excellent biocompatibility for biological Nanofluid and cell interface applications are of great value,†said Jia Geng, the first co-author and postdoctoral researcher.
Kyunghoon Kim, another research collaborator and postdoctoral researcher, added: "We also hope to modify the 'gate' of the synthesis of carbon nanotubes, which greatly alters their selectivity and opens them in synthetics. New possibilities for cell, drug delivery and biosensing.†Other research authors include Ramya Tunuguntla and Kang Rae Cho at Lawrence Livermore National Laboratory. , Dayannara Munoz and Morris Wang.
Source: Phoenix Technology
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