Reasons for the weight loss of the tablet press and the treatment method: The weight difference of the tablet means that the difference in the weight of the tablet exceeds the limit prescribed by the Pharmacopoeia.
1. The particle size distribution is uneven. The particle flow rate is different when the tablet is pressed, resulting in uneven grain thickness in the middle die hole. For example, the amount of coarse particles is light, and the fine particles are heavy. ★ Solution: Mix the granules or sieve out too much fine powder.
2. If the fine powder adheres to the punch and causes the slamming, the difference in the weight of the tablet can be made larger. ★Solution: At this time, the undershooting rotation is not flexible. It should be checked in time, the die is removed, and the lower punch and the middle die hole are cleaned.
3, the particle flow is not good, the amount of particles flowing into the middle die hole is often too small, causing the difference in the weight of the film to be too large and overrun. ★ Solution: Re-granulation or adding a suitable glidant such as micro-silica gel to improve particle flow.
4. Particle stratification. ★ Solution: particle stratification, reducing the difference in particle size.
5. Smaller tablets use larger particles. ★ Solution: Select the appropriate size of the particles.
6. The hopper is blocked. This phenomenon often occurs in drugs with strong viscosity or moisture permeability. ★ Solution: The hopper should be dredged, the tableting environment should be kept dry, and the flow aid should be added properly.
7. There is a big difference in the amount of material stored in the material. ★ Solution: Control within 50%.
8. The feeder is unbalanced or not installed in place, resulting in uneven packing. ★ Solution: Balance the feeder or install it in place.
9. The scraping board is not flat or poorly installed. Solution: Leveling.
10. With the forced feeder, the forced feeder dial speed does not match the turntable speed. ★ Solution: Adjust the same.
11. The punch and the middle die hole are not well matched. For example, more powder is leaked between the outer periphery of the undershoot and the wall of the die hole, causing the phenomenon of "shocking" under the undershoot, resulting in insufficient material filling. ★ Solution: Replace the punch and the middle mold with this.
12, the length of the undershoot is different, the difference is poor, resulting in uneven filling. ★ Solution: Repair the difference, within ±5μm.
13. The undershoot is damped, and the damping force of the damper screw adjustment is not good. ★ Solution: Re-adjust.
14. The filling track is worn or the filling mechanism is unstable. ★ Solution: Replace or stabilize.
15. Pursuing the output, the rotation speed of the turntable is too fast, and the filling amount is insufficient. ★Solution: Especially when pressing large pieces, it is necessary to reduce the rotation speed properly to ensure filling.
16. The tablet press is too large, the structure is loose, the assembly is unreasonable or reassembled; the pressure setting of the tablet press is too large, ★ Solution: Reduce the pressure.
1. The particle size distribution is uneven. The particle flow rate is different when the tablet is pressed, resulting in uneven grain thickness in the middle die hole. For example, the amount of coarse particles is light, and the fine particles are heavy. ★ Solution: Mix the granules or sieve out too much fine powder.
2. If the fine powder adheres to the punch and causes the slamming, the difference in the weight of the tablet can be made larger. ★Solution: At this time, the undershooting rotation is not flexible. It should be checked in time, the die is removed, and the lower punch and the middle die hole are cleaned.
3, the particle flow is not good, the amount of particles flowing into the middle die hole is often too small, causing the difference in the weight of the film to be too large and overrun. ★ Solution: Re-granulation or adding a suitable glidant such as micro-silica gel to improve particle flow.
4. Particle stratification. ★ Solution: particle stratification, reducing the difference in particle size.
5. Smaller tablets use larger particles. ★ Solution: Select the appropriate size of the particles.
6. The hopper is blocked. This phenomenon often occurs in drugs with strong viscosity or moisture permeability. ★ Solution: The hopper should be dredged, the tableting environment should be kept dry, and the flow aid should be added properly.
7. There is a big difference in the amount of material stored in the material. ★ Solution: Control within 50%.
8. The feeder is unbalanced or not installed in place, resulting in uneven packing. ★ Solution: Balance the feeder or install it in place.
9. The scraping board is not flat or poorly installed. Solution: Leveling.
10. With the forced feeder, the forced feeder dial speed does not match the turntable speed. ★ Solution: Adjust the same.
11. The punch and the middle die hole are not well matched. For example, more powder is leaked between the outer periphery of the undershoot and the wall of the die hole, causing the phenomenon of "shocking" under the undershoot, resulting in insufficient material filling. ★ Solution: Replace the punch and the middle mold with this.
12, the length of the undershoot is different, the difference is poor, resulting in uneven filling. ★ Solution: Repair the difference, within ±5μm.
13. The undershoot is damped, and the damping force of the damper screw adjustment is not good. ★ Solution: Re-adjust.
14. The filling track is worn or the filling mechanism is unstable. ★ Solution: Replace or stabilize.
15. Pursuing the output, the rotation speed of the turntable is too fast, and the filling amount is insufficient. ★Solution: Especially when pressing large pieces, it is necessary to reduce the rotation speed properly to ensure filling.
16. The tablet press is too large, the structure is loose, the assembly is unreasonable or reassembled; the pressure setting of the tablet press is too large, ★ Solution: Reduce the pressure.
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