Imitation virus nanoparticles are expected to achieve "toxin attack"
October 10, 2018 Source: Science and Technology Daily
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];In the battle against the virus, the martial arts world's "drug attack" is expected to be realized. Professor Qi Wei from the School of Chemical Engineering of Tianjin University used the natural virus targeting characteristics to redesign the peptide sequence and adopt the peptide self-assembly strategy to successfully prepare non-pathogenic, transmembrane and directional delivery of virus-like nanoparticles. Like a "Trojan horse", it can successfully mix into the virus circle and send genetic drugs to their destinations. The results of this research were published online in the international journal "Applied Chemistry of Germany" in the field of chemistry.
The virus is a nanoparticle formed by the co-assembly of nucleic acids and proteins. Due to the unique envelope protein structure on the surface of the virus, it can bind to the host cell receptor protein to achieve specific cell infection and genetic material delivery. . Through the simulation and biomimetic of viral functional proteins, it is expected that non-pathogenic, genetically-carrying drugs with targeted recognition characteristics will be obtained for the treatment of related diseases. However, due to the complexity of the virus structure, how to accurately prepare the imitation virus particles by simple molecules, and how to effectively assemble the polypeptide sequence, the efficient imitation of the virus transmembrane behavior is still full of challenges.
Professor Qi Qi's team got inspiration from the life system. By simulating the active center of the natural enzyme and the functional protein structure of the virus, the peptide-based assembly with biocatalysis and targeted recognition was obtained, which realized material conversion and drug delivery. In the experiment, based on the nuclear localization sequence of the variable region polypeptide on the HIV surface envelope protein and the large T antigen protein molecule of the simian vacuolating virus, they designed two kinds of membranes and nuclear membranes through molecular and nano-biomimetic techniques. Functional peptides, through the regulation of the assembly of viral polypeptides, successfully produced pseudo-viral nanoparticles. The results show that the particle is like a "Trojan horse", which can carry nucleic acid gene drugs, and delivers the drug to immune cells in a virus-like transmembrane manner, and also exhibits good biocompatibility during gene delivery. Biological activity and directional transport characteristics provide new ways and options for targeted therapy of human viral diseases in the future. (Reporter Sun Yusong correspondent Liu Xiaoyan)
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